AS 2553627( AS2553627 | AS-2553627 )

Catalog No. M11009 CAS No. 1251906-07-6

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Product Name

AS 2553627
Note

Research use only, not for human use.
Brief Description

AS 2553627 (AS2553627)?is a novel potent, selective pan-JAK inhibitor.
Description

AS 2553627 (AS2553627)?is a novel potent, selective pan-JAK inhibitor with IC50 of 0.46, 0.30, 0.14 and 2.0 nM for JAK1, JAK2, JAK3 and TYK2, respectively; displays no inhibitory activity against a panel of protein kinases, including SYK and ZAP70 at 1 uM; inhibits proliferation of IL-2 stimulated human and rat T cells with IC50 of 2.4 and 4.3 nM, respectively, inhibits the proliferation of TF-1 cells stimulated with EPO with IC50 of 12 nM; effectively prevents chronic rejection in rat cardiac allografts in rat cardiac transplant model alone or co-administration with tacrolimus.
In Vitro

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In Vivo

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Synonyms

AS2553627 | AS-2553627
Pathway

Angiogenesis
Target

JAK
Recptor

JAK
Research Area

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Indication

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CAS Number

1251906-07-6
Formula Weight

321.384
Molecular Formula

C18H19N5O
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

3-((3R,4R)-3-(dipyrrolo[2,3-b:2',3'-d]pyridin-1(6H)-yl)-4-methylpiperidin-1-yl)-3-oxopropanenitrile

1. Nakamura K, et al. Eur J Pharmacol. 2017 Feb 5;796:69-75. 2. Nakamura K, et al. Transpl Immunol. 2017 Oct 5. pii: S0966-3274(17)30038-2.

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